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Millions of Americans have arthritis and other painful health problems affecting the musculoskeletal system: the joints, muscles and bones. A mainstay of treatment for these conditions for more than three decades has been a class of medications known as nonsteroidal anti-inflammatory drugs or NSAIDs.

Traditional NSAIDs include aspirin, ibuprofen (Advil, Motrin, etc.), naproxen (e.g., Aleve) and many other generic and brand name drugs. Celecoxib (Celebrex) belongs to a newer class of NSAIDs, which doctors call a “COX-2 inhibitor” or a “COX-2 selective” NSAID.

Source: American College of Rheumatology